Science & Research

In addition to ongoing clinical studies, supportive preclinical research has been conducted to better understand how modulating inflammation, lymphatic function, adipose tissue remodeling, and fibrosis may influence tissue-level changes.

In established animal models of lymphedema, investigational compounds from Celltaxis have been studied using tissue histology and structural analyses. These preclinical evaluations have demonstrated:

• Reductions in dermal and subcutaneous tissue thickening
• Decreased inflammatory cell infiltration
• Reversal of fibrotic remodeling
• Normalization of epidermal tissue structure
• Improvement toward more normalized adipocyte tissue architecture

These preclinical findings provide biological support for the mechanisms under investigation and are consistent with areas being evaluated in ongoing human clinical studies. While animal model findings do not necessarily predict clinical outcomes, they help inform study design and deepen understanding of disease biology.